Very much the same as Dave.
Regular updates of patches, two AVs [there paranoia for you] constantly updated, firewall and antispyware.
Again, like Dave I write my own scripts and keep 'em as tight as possible.
I usually use the mnemonic method of generating passwords [i.e. "Irish Webmaster Forum is a good resource for webmasters" translates to "IWFiagr4w" which is easily remembered but difficult to crack].
The only people who needn't worry about security are those who use their PCs for the sole purpose of viewing pages on the Internet. They don't run any other application such as word processors. They don't shop on-line or fill in any forms with personal info. They don't use e-mail. They hold no info on their hard drives bar the OS. In short, very few!!!
And after all the above, I still worry