As this comes up here and elsewhere quite a bit I think it deserves its own sticky.

PhpList - Php / MySQL email list management. Read the documentation carefully, as it won't send any mail until you edit one variable

DadaMail - Perl email list management software.

GroupMail - Windows based mass email software (Irish made!). Free version available with some limitations.

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Nice post, I get this question all the time too.

Campaign Monitor Web based mass mail, list managment and tracking.

Hi, I use SpinnakerPro - check out Email Marketing Ireland : Email Marketing Software and Email Marketing Service from SpinnakerPro . Easy to use, great support. They offer a full service or self service hosted option...pricing is good as well.

Toddle - for creating great looking newsletters in the first place.
Can be sent with most of the email managers mentioned above.

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Spoiltchild Design - Effective business design.

CustomerMinds.com

Enables you to send email and mobile campaigns and does all the tracking for you as well as providing you with reports and success figures.